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Anti-Human GBP5 Polyclonal Antibody (ARO-A12591)

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概述
货号ARO-A12591
品牌ProteoGenix
描述
Anti-Human GBP5 Polyclonal Antibody (ARO-A12591) is a rabbit polyclonal antibody detecting GBP5, GBP-TA antigen, GTP-binding protein 5, Guanine nucleotide-binding protein 5, GBP-5, Guanylate-binding protein 5 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GBP5 (Met1-Gly305).
靶标GBP5, GBP-TA antigen, GTP-binding protein 5, Guanine nucleotide-binding protein 5, GBP-5, Guanylate-binding protein 5
纯化方式Purified by antigen affinity column.
Accession号Q96PP8
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Guanylate-binding protein 5 (GBP5) is a ~66 kDa protein. Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome.

1. Wehner, M. et al. (2010) The FEBS journal 277, 1597-605. PMID: 20180847
2. Shenoy, AR. et al. (2012) Science (New York, N.Y.) 336, 481-5. PMID: 22461501
3. Krapp, C. et al. (2016) Cell host & microbe 19, 504-14. PMID: 26996307
4. Braun, E. et al. (2019) Cell reports 27, 2092-2104.e10. PMID: 31091448
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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