Anti-Human VPS16 Polyclonal Antibody (HP969014)

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50ug
100ug

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概述
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参考文献
产品说明书

HP969014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human VPS16 (Lys492-Lys839).

hVPS16, VPS16, Vacuolar protein sorting-associated protein 16 homolog

Purified by antigen affinity column.

Accession号

Q9H269

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Vacuolar protein sorting-associated protein 16 homolog (VPS16) is a ~94 kDa protein. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of VPS33A to the HOPS complex.

1. Kim, BY. et al. (2001) The Journal of biological chemistry 276, 29393-402. PMID: 11382755

2. Solinger, JA. et al. (2013) The FEBS journal 280, 2743-57. PMID: 23351085

3. Jiang, P. et al. (2014) Molecular biology of the cell 25, 1327-37. PMID: 24554770

4. Perini, ED. et al. (2014) Traffic (Copenhagen, Denmark) 15, 1366-89. PMID: 25266290

5. Wartosch, L. et al. (2015) Traffic (Copenhagen, Denmark) 16, 727-42. PMID: 25783203

6. Graham, SC. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 13345-50. PMID: 23901104

For research use only.

Western blot

Western blot analysis was performed using anti-VPS16 polyclonal antibody at 1μg/ml on various samples.
Lane 1: A549 cell lysate
Lane 2: MOLT-4 cell lysate

产品说明书

Anti-Human VPS16 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human VPS16 Polyclonal Antibody (HP969014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human VPS16 Polyclonal Antibody (HP969014)

概述

图片

参考文献

产品说明书

相关产品推荐

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