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Anti-Human VPS16 Polyclonal Antibody (ARO-A12401)

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概述
货号ARO-A12401
品牌ProteoGenix
描述
Anti-Human VPS16 Polyclonal Antibody (ARO-A12401) is a rabbit polyclonal antibody detecting hVPS16, VPS16, Vacuolar protein sorting-associated protein 16 homolog in ELISA, IHC, WB. Suitable for Human, Mouse, Bos taurus.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Bos taurus
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human VPS16 (Lys492-Lys839).
靶标hVPS16, VPS16, Vacuolar protein sorting-associated protein 16 homolog
纯化方式Purified by antigen affinity column.
Accession号Q9H269
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Vacuolar protein sorting-associated protein 16 homolog (VPS16) is a ~94 kDa protein. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of VPS33A to the HOPS complex.

1. Kim, BY. et al. (2001) The Journal of biological chemistry 276, 29393-402. PMID: 11382755
2. Solinger, JA. et al. (2013) The FEBS journal 280, 2743-57. PMID: 23351085
3. Jiang, P. et al. (2014) Molecular biology of the cell 25, 1327-37. PMID: 24554770
4. Perini, ED. et al. (2014) Traffic (Copenhagen, Denmark) 15, 1366-89. PMID: 25266290
5. Wartosch, L. et al. (2015) Traffic (Copenhagen, Denmark) 16, 727-42. PMID: 25783203
6. Graham, SC. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 13345-50. PMID: 23901104
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human VPS16 Polyclonal Antibody

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