Anti-Human LARP7 Polyclonal Antibody (HS837014)

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规格：

50ug
100ug

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概述
图片
参考文献
产品说明书

HS837014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human LARP7 (Met1-Asn187).

La ribonucleoprotein domain family member 7, La-related protein 7, hLARP7, P-TEFb-interaction protein for 7SK stability, LARP7, PIP7S

Purified by antigen affinity column.

Accession号

Q4G0J3

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

La-related protein 7 (LARP7) is a ~66 kDa protein. RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex.

1. He, N. et al. (2008) Molecular cell 29, 588-99. PMID: 18249148

2. Hasler, D. et al. (2020) Molecular cell 77, 1014-1031.e13. PMID: 32017898

3. Markert, A. et al. (2008) EMBO reports 9, 569-75. PMID: 18483487

4. Egloff, S. et al. (2017) The EMBO journal 36, 934-948. PMID: 28254838

5. Krueger, BJ. et al. (2008) Nucleic acids research 36, 2219-29. PMID: 18281698

For research use only.

产品说明书

Anti-Human LARP7 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LARP7 Polyclonal Antibody (HS837014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LARP7 Polyclonal Antibody (HS837014)

概述

图片

参考文献

产品说明书

相关产品推荐

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