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Anti-Human LARP7 Polyclonal Antibody (ARO-A12400)

概述
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参考文献

概述

货号	ARO-A12400
品牌	ProteoGenix
描述	Anti-Human LARP7 Polyclonal Antibody (ARO-A12400) is a rabbit polyclonal antibody detecting La ribonucleoprotein domain family member 7, La-related protein 7, hLARP7, P-TEFb-interaction protein for 7SK stability, LARP7, PIP7S in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Macaca fascicularis. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications. Multi-Species — Cross-reactive for translational research.
种属反应性	Human, Mouse, Rat, Macaca fascicularis
应用	ELISA, IHC, WB
宿主	Rabbit
克隆类型	Polyclonal
同种型	IgG
免疫原	E. coli - derived recombinant Human LARP7 (Met1-Asn187).
靶标	La ribonucleoprotein domain family member 7, La-related protein 7, hLARP7, P-TEFb-interaction protein for 7SK stability, LARP7, PIP7S
纯化方式	Purified by antigen affinity column.
Accession号	Q4G0J3
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	La-related protein 7 (LARP7) is a ~66 kDa protein. RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. 1. He, N. et al. (2008) Molecular cell 29, 588-99. PMID: 18249148 2. Hasler, D. et al. (2020) Molecular cell 77, 1014-1031.e13. PMID: 32017898 3. Markert, A. et al. (2008) EMBO reports 9, 569-75. PMID: 18483487 4. Egloff, S. et al. (2017) The EMBO journal 36, 934-948. PMID: 28254838 5. Krueger, BJ. et al. (2008) Nucleic acids research 36, 2219-29. PMID: 18281698
Note	For research use only.

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参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

=

浓度

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体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

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V₁ (起始体积)

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工作液

C₂ (终浓度)

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V₂ (终体积)

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Anti-Human LARP7 Polyclonal Antibody

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