Anti-Human FBXO22 Polyclonal Antibody (HP533014)

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50ug
100ug

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概述
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HP533014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human FBXO22 (Arg61-Lys403).

FBX22, F-box protein FBX22p44, FBXO22, F-box only protein 22

Purified by antigen affinity column.

Accession号

Q8NEZ5

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

F-box only protein 22 (FBXO22) is a ~44 kDa protein. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels. In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage. Under oxidative stress, promotes the ubiquitination and degradation of BACH1.

1. Tan, MK. et al. (2011) Molecular and cellular biology 31, 3687-99. PMID: 21768309

2. Johmura, Y. et al. (2016) Nature communications 7, 10574. PMID: 26868148

3. Cao, S. et al. (2024) Cell 187, 7568-7584.e22. PMID: 39504958

4. Ge, MK. et al. (2023) Cell metabolism 35, 2216-2230.e8. PMID: 37979583

5. Zhou, Y. et al. (2024) Journal of medical virology 96, e29891. PMID: 39223933

For research use only.

产品说明书

Anti-Human FBXO22 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human FBXO22 Polyclonal Antibody (HP533014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human FBXO22 Polyclonal Antibody (HP533014)

概述

图片

参考文献

产品说明书

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