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Anti-Human FBXO22 Polyclonal Antibody (ARO-A12394)

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概述
货号ARO-A12394
品牌ProteoGenix
描述
Anti-Human FBXO22 Polyclonal Antibody (ARO-A12394) is a rabbit polyclonal antibody detecting FBX22, F-box protein FBX22p44, FBXO22, F-box only protein 22 in ELISA, IHC, WB. Suitable for Human, Mouse, Pongo abelii.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Pongo abelii
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human FBXO22 (Arg61-Lys403).
靶标FBX22, F-box protein FBX22p44, FBXO22, F-box only protein 22
纯化方式Purified by antigen affinity column.
Accession号Q8NEZ5
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

F-box only protein 22 (FBXO22) is a ~44 kDa protein. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels. In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage. Under oxidative stress, promotes the ubiquitination and degradation of BACH1.

1. Tan, MK. et al. (2011) Molecular and cellular biology 31, 3687-99. PMID: 21768309
2. Johmura, Y. et al. (2016) Nature communications 7, 10574. PMID: 26868148
3. Cao, S. et al. (2024) Cell 187, 7568-7584.e22. PMID: 39504958
4. Ge, MK. et al. (2023) Cell metabolism 35, 2216-2230.e8. PMID: 37979583
5. Zhou, Y. et al. (2024) Journal of medical virology 96, e29891. PMID: 39223933
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human FBXO22 Polyclonal Antibody

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