

| 货号 | HP455014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SH3PXD2A (Met1-Asn129). | ||||||||
| 靶标 | KIAA0418, Tyrosine kinase substrate with five SH3 domains, TKS5, SH3 multiple domains protein 1, SH3PXD2A, SH3MD1, SH3 and PX domain-containing protein 2A, Five SH3 domain-containing protein, Adapter protein TKS5, FISH | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q5TCZ1 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | SH3 and PX domain-containing protein 2A (SH3PXD2A) is a ~125 kDa protein. Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. 1. Jacob, A. et al. (2016) Journal of cell science 129, 4341-4353. PMID: 27789576 | ||||||||
| Note | For research use only. |

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