Anti-Human SHOC2 Polyclonal Antibody (HP134014)

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50ug
100ug

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概述
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参考文献
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HP134014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human SHOC2 (Ser86-Val582).

Leucine-rich repeat protein SHOC-2, KIAA0862, Protein sur-8 homolog, Protein soc-2 homolog, SHOC2

Purified by antigen affinity column.

Accession号

Q9UQ13

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Leucine-rich repeat protein SHOC-2 (SHOC2) is a ~64 kDa protein. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.

1. Li, W. et al. (2000) Genes & development 14, 895-900. PMID: 10783161

2. Rodriguez-Viciana, P. et al. (2006) Molecular cell 22, 217-30. PMID: 16630891

3. Hannig, V. et al. (2014) Human mutation 35, 1290-4. PMID: 25137548

4. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504

5. Hauseman, ZJ. et al. (2022) Nature 609, 416-423. PMID: 35830882

6. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509

7. Bonsor, DA. et al. (2022) Nature structural & molecular biology 29, 966-977. PMID: 36175670

For research use only.

产品说明书

Anti-Human SHOC2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SHOC2 Polyclonal Antibody (HP134014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SHOC2 Polyclonal Antibody (HP134014)

概述

图片

参考文献

产品说明书

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