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Anti-Human SHOC2 Polyclonal Antibody (ARO-A12342)

概述
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参考文献

概述

货号	ARO-A12342
品牌	ProteoGenix
描述	Anti-Human SHOC2 Polyclonal Antibody (ARO-A12342) is a rabbit polyclonal antibody detecting Leucine-rich repeat protein SHOC-2, KIAA0862, Protein sur-8 homolog, Protein soc-2 homolog, SHOC2 in ELISA, IHC, WB. Suitable for Human. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications.
种属反应性	Human
应用	ELISA, IHC, WB
宿主	Rabbit
克隆类型	Polyclonal
同种型	IgG
免疫原	E. coli - derived recombinant Human SHOC2 (Ser86-Val582).
靶标	Leucine-rich repeat protein SHOC-2, KIAA0862, Protein sur-8 homolog, Protein soc-2 homolog, SHOC2
纯化方式	Purified by antigen affinity column.
Accession号	Q9UQ13
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Leucine-rich repeat protein SHOC-2 (SHOC2) is a ~64 kDa protein. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c. 1. Li, W. et al. (2000) Genes & development 14, 895-900. PMID: 10783161 2. Rodriguez-Viciana, P. et al. (2006) Molecular cell 22, 217-30. PMID: 16630891 3. Hannig, V. et al. (2014) Human mutation 35, 1290-4. PMID: 25137548 4. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504 5. Hauseman, ZJ. et al. (2022) Nature 609, 416-423. PMID: 35830882 6. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509 7. Bonsor, DA. et al. (2022) Nature structural & molecular biology 29, 966-977. PMID: 36175670
Note	For research use only.

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参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

=

浓度

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体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

×

V₁ (起始体积)

=

工作液

C₂ (终浓度)

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V₂ (终体积)

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Anti-Human SHOC2 Polyclonal Antibody

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