mRNA decay activator protein ZFP36 is a ~34 kDa protein. Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA. 1. Lai, WS. et al. (1999) Molecular and cellular biology 19, 4311-23. PMID: 103301722. Lai, WS. et al. (2000) The Journal of biological chemistry 275, 17827-37. PMID: 107514063. Lai, WS. et al. (2001) The Journal of biological chemistry 276, 23144-54. PMID: 112792394. Brooks, SA. et al. (2002) Arthritis and rheumatism 46, 1362-70. PMID: 121152445. Lai, WS. et al. (2003) Molecular and cellular biology 23, 3798-812. PMID: 127482836. Brooks, SA. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 7263-71. PMID: 151871017. Ogilvie, RL. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 953-61. PMID: 156349189. Lai, WS. et al. (2006) Molecular and cellular biology 26, 9196-208. PMID: 17030620 | 
