Anti-Human FZR1 Polyclonal Antibody (HP589014)

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规格：

50ug
100ug

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参考文献
产品说明书

HP589014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human FZR1 (Ser172-Arg496).

FZR, hCDH1, Fizzy-related protein homolog, Cdh1/Hct1 homolog, Fzr, CDH1, CDC20-like protein 1, KIAA1242, FYR, FZR1

Purified by antigen affinity column.

Accession号

Q9UM11

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fizzy-related protein homolog (FZR1) is a ~55 kDa protein. Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

1. Lafranchi, L. et al. (2014) The EMBO journal 33, 2860-79. PMID: 25349192

For research use only.

Western blot

Western blot analysis was performed using anti-FZR1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: Jurkat cell lysate
Lane 4: PC-3 cell lysate

产品说明书

Anti-Human FZR1 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

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实验相关试剂

Anti-Human FZR1 Polyclonal Antibody (HP589014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human FZR1 Polyclonal Antibody (HP589014)

概述

图片

参考文献

产品说明书

相关产品推荐

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