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Anti-Human FZR1 Polyclonal Antibody (ARO-A12322)

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概述
货号ARO-A12322
品牌ProteoGenix
描述
Anti-Human FZR1 Polyclonal Antibody (ARO-A12322) is a rabbit polyclonal antibody detecting FZR, hCDH1, Fizzy-related protein homolog, Cdh1/Hct1 homolog, Fzr, CDH1, CDC20-like protein 1, KIAA1242, FYR, FZR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human FZR1 (Ser172-Arg496).
靶标FZR, hCDH1, Fizzy-related protein homolog, Cdh1/Hct1 homolog, Fzr, CDH1, CDC20-like protein 1, KIAA1242, FYR, FZR1
纯化方式Purified by antigen affinity column.
Accession号Q9UM11
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Fizzy-related protein homolog (FZR1) is a ~55 kDa protein. Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

1. Lafranchi, L. et al. (2014) The EMBO journal 33, 2860-79. PMID: 25349192
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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