Anti-Human PSMD14 Polyclonal Antibody (HT284014)

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50ug
100ug

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概述
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参考文献
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HT284014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human PSMD14 (Gln30-Lys209).

26S proteasome non-ATPase regulatory subunit 14, 26S proteasome-associated PAD1 homolog 1, POH1, 26S proteasome regulatory subunit RPN11, PSMD14

Purified by antigen affinity column.

Accession号

O00487

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Ubiquitin C-terminal hydrolase PSMD14 is a ~34 kDa protein. Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation.

1. Spataro, V. et al. (1997) The Journal of biological chemistry 272, 30470-5. PMID: 9374539

2. Kanayama, HO. et al. (1992) European journal of biochemistry 206, 567-78. PMID: 1317798

3. Butler, LR. et al. (2012) The EMBO journal 31, 3918-34. PMID: 22909820

4. Bustamante, HA. et al. (2020) Cells 9. PMID: 32210007

For research use only.

产品说明书

Anti-Human PSMD14 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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实验相关试剂

Anti-Human PSMD14 Polyclonal Antibody (HT284014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PSMD14 Polyclonal Antibody (HT284014)

概述

图片

参考文献

产品说明书

相关产品推荐

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