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Anti-Human PSMD14 Polyclonal Antibody (PTX20159)

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概述
货号PTX20159
品牌ProteoGenix
描述
Anti-Human PSMD14 Polyclonal Antibody (PTX20159) is a rabbit polyclonal antibody detecting 26S proteasome non-ATPase regulatory subunit 14, 26S proteasome-associated PAD1 homolog 1, POH1, 26S proteasome regulatory subunit RPN11, PSMD14 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human PSMD14 (Gln30-Lys209).
靶标26S proteasome non-ATPase regulatory subunit 14, 26S proteasome-associated PAD1 homolog 1, POH1, 26S proteasome regulatory subunit RPN11, PSMD14
纯化方式Purified by antigen affinity column.
Accession号O00487
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ubiquitin C-terminal hydrolase PSMD14 is a ~34 kDa protein. Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation.

1. Spataro, V. et al. (1997) The Journal of biological chemistry 272, 30470-5. PMID: 9374539
2. Kanayama, HO. et al. (1992) European journal of biochemistry 206, 567-78. PMID: 1317798
3. Butler, LR. et al. (2012) The EMBO journal 31, 3918-34. PMID: 22909820
4. Bustamante, HA. et al. (2020) Cells 9. PMID: 32210007
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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