Anti-Human VHL Polyclonal Antibody (HW527014)

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50ug
100ug

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HW527014

abinScience

种属反应性

Human, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human VHL (Glu70-Asp213).

VHL, pVHL, Protein G7, von Hippel-Lindau disease tumor suppressor

Purified by antigen affinity column.

Accession号

P40337

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

von Hippel-Lindau disease tumor suppressor (VHL) is a ~24 kDa protein. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.

1. Tanimoto, K. et al. (2000) The EMBO journal 19, 4298-309. PMID: 10944113

2. Cheng, J. et al. (2007) Cell 131, 584-95. PMID: 17981124

3. Xie, L. et al. (2009) Science signaling 2, ra33. PMID: 19584355

4. Ganner, A. et al. (2021) Scientific reports 11, 14827. PMID: 34290272

For research use only.

产品说明书

Anti-Human VHL Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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Anti-Human VHL Polyclonal Antibody (HW527014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human VHL Polyclonal Antibody (HW527014)

概述

图片

参考文献

产品说明书

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