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Anti-Human VHL Monoclonal Antibody (1A521) (HW527015)

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概述
货号HW527015
品牌abinScience
描述
Anti-Human VHL Monoclonal Antibody (1A521) [1A521] (HW527015) is a mouse monoclonal antibody detecting VHL in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
同种型IgG
克隆号1A521
克隆类型Monoclonal
免疫原E. coli - derived recombinant human VHL (Glu70-Asp213).
靶标von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P40337
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

von Hippel-Lindau disease tumor suppressor (VHL) is a ~24 kDa protein. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.

1. Tanimoto, K. et al. (2000) The EMBO journal 19, 4298-309. PMID: 10944113
2. Cheng, J. et al. (2007) Cell 131, 584-95. PMID: 17981124
3. Xie, L. et al. (2009) Science signaling 2, ra33. PMID: 19584355
4. Ganner, A. et al. (2021) Scientific reports 11, 14827. PMID: 34290272
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human VHL Monoclonal Antibody (1A521)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human VHL Monoclonal Antibody (1A521)

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