Anti-Human WDR48 Polyclonal Antibody (HP117014)

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100ug

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HP117014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human WDR48 (Gly32-Lys358).

USP1-associated factor 1, WD repeat-containing protein 48, KIAA1449, WDR48, p80, WD repeat endosomal protein, UAF1

Purified by antigen affinity column.

Accession号

Q8TAF3

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

WD repeat-containing protein 48 (WDR48) is a ~76 kDa protein. Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.

1. Cohn, MA. et al. (2007) Molecular cell 28, 786-97. PMID: 18082604

2. Cohn, MA. et al. (2009) The Journal of biological chemistry 284, 5343-51. PMID: 19075014

3. Yin, J. et al. (2015) Structure (London, England : 1993) 23, 2043-54. PMID: 26388029

4. Liang, F. et al. (2019) Nature communications 10, 2849. PMID: 31253762

5. Li, H. et al. (2016) Molecular cell 63, 249-260. PMID: 27373336

7. Gangula, NR. et al. (2013) The Journal of biological chemistry 288, 34545-54. PMID: 24145035

For research use only.

产品说明书

Anti-Human WDR48 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human WDR48 Polyclonal Antibody (HP117014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human WDR48 Polyclonal Antibody (HP117014)

概述

图片

参考文献

产品说明书

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