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Anti-Human WDR48 Polyclonal Antibody (ARO-A12117)

概述
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概述

货号	ARO-A12117
品牌	ProteoGenix
描述	Anti-Human WDR48 Polyclonal Antibody (ARO-A12117) is a rabbit polyclonal antibody detecting USP1-associated factor 1, WD repeat-containing protein 48, KIAA1449, WDR48, p80, WD repeat endosomal protein, UAF1 in ELISA, IHC, WB. Suitable for Human. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications.
种属反应性	Human
应用	ELISA, IHC, WB
宿主	Rabbit
克隆类型	Polyclonal
同种型	IgG
免疫原	E. coli - derived recombinant Human WDR48 (Gly32-Lys358).
靶标	USP1-associated factor 1, WD repeat-containing protein 48, KIAA1449, WDR48, p80, WD repeat endosomal protein, UAF1
纯化方式	Purified by antigen affinity column.
Accession号	Q8TAF3
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	WD repeat-containing protein 48 (WDR48) is a ~76 kDa protein. Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability. 1. Cohn, MA. et al. (2007) Molecular cell 28, 786-97. PMID: 18082604 2. Cohn, MA. et al. (2009) The Journal of biological chemistry 284, 5343-51. PMID: 19075014 3. Yin, J. et al. (2015) Structure (London, England : 1993) 23, 2043-54. PMID: 26388029 4. Liang, F. et al. (2019) Nature communications 10, 2849. PMID: 31253762 5. Li, H. et al. (2016) Molecular cell 63, 249-260. PMID: 27373336 7. Gangula, NR. et al. (2013) The Journal of biological chemistry 288, 34545-54. PMID: 24145035
Note	For research use only.

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Anti-Human WDR48 Polyclonal Antibody

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