

| 货号 | HC684014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HTR4 (Arg214-Thr260). | ||||||||
| 靶标 | HTR4, Serotonin receptor 4, 5-HT-4, 5-HT4, 5-hydroxytryptamine receptor 4 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q13639 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 5-hydroxytryptamine receptor 4 (HTR4) is a ~43 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. 1. Mialet, J. et al. (2000) British journal of pharmacology 130, 527-38. PMID: 10821780 2. Kamel, R. et al. (2005) Biochemical pharmacology 70, 1009-18. PMID: 16102731 3. Huang, S. et al. (2022) Molecular cell 82, 2681-2695.e6. PMID: 35714614 4. Blondel, O. et al. (1998) Journal of neurochemistry 70, 2252-61. PMID: 9603189 | ||||||||
| Note | For research use only. |

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