| 背景 | Solute carrier organic anion transporter family member 2A1 (SLCO2A1) is a ~70 kDa protein. Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane. PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever. Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination. PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions. Uses lactate, generated by glycolysis, as a counter-substrate to mediate PGE2 influx and efflux. 1. Chan, BS. et al. (2002) American journal of physiology. Renal physiology 282, F1097-102. PMID: 119973262. Gose, T. et al. (2016) Prostaglandins & other lipid mediators 122, 10-7. PMID: 266922853. Lu, R. et al. (1996) The Journal of clinical investigation 98, 1142-9. PMID: 87876774. Nomura, T. et al. (2004) Molecular pharmacology 65, 973-8. PMID: 150446275. Nakanishi, T. et al. (2017) The AAPS journal 20, 13. PMID: 292049666. Kang, J. et al. (2006) Human reproduction (Oxford, England) 21, 592-9. PMID: 16339169 |
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