ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
12.97 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
OATP2A1, PGT, PHOAR2, Prostaglandin transporter, SLC21A2, SLCO2A1, Solute carrier family 21 member 2, Solute carrier organic anion transporter family member 2A1
背景
Solute carrier organic anion transporter family member 2A1 is a ~70 kDa protein. Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane. PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever. Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination. PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions. Uses lactate, generated by glycolysis, as a counter-substrate to mediate PGE2 influx and efflux.
1. Chan, BS. et al. (2002) American journal of physiology. Renal physiology 282, F1097-102. PMID: 11997326
2. Gose, T. et al. (2016) Prostaglandins & other lipid mediators 122, 10-7. PMID: 26692285
3. Lu, R. et al. (1996) The Journal of clinical investigation 98, 1142-9. PMID: 8787677
4. Nomura, T. et al. (2004) Molecular pharmacology 65, 973-8. PMID: 15044627
5. Nakanishi, T. et al. (2017) The AAPS journal 20, 13. PMID: 29204966
6. Kang, J. et al. (2006) Human reproduction (Oxford, England) 21, 592-9. PMID: 16339169
