

| 货号 | HP315014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCA7 (Asp1773-Asp2121). | ||||||||
| 靶标 | Macrophage ABC transporter, ABCA-SSN, ATP-binding cassette sub-family A member 7, Autoantigen SS-N, Phospholipid-transporting ATPase ABCA7, ABCA7 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q8IZY2 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phospholipid-transporting ATPase ABCA7 is a ~234 kDa protein. Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Transports preferentially phosphatidylserine over phosphatidylcholine. Plays a role in lipid homeostasis and macrophage-mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. 1. Quazi, F. et al. (2013) The Journal of biological chemistry 288, 34414-26. PMID: 24097981 2. Wang, N. et al. (2003) The Journal of biological chemistry 278, 42906-12. PMID: 12917409 3. Kielar, D. et al. (2003) The Journal of investigative dermatology 121, 465-74. PMID: 12925201 4. Abe-Dohmae, S. et al. (2004) The Journal of biological chemistry 279, 604-11. PMID: 14570867 5. Ikeda, Y. et al. (2003) Biochemical and biophysical research communications 311, 313-8. PMID: 14592415 | ||||||||
| Note | For research use only. |

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