Anti-Human CUL2 Polyclonal Antibody (HC301014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

HC301014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human CUL2 (Thr526-Ala745).

Cullin-2, CUL2, CUL-2

Purified by antigen affinity column.

Accession号

Q13617

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Cullin-2 (CUL2) is a ~86 kDa protein. Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. CUL2 serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the E2 ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

1. Kamura, T. et al. (2001) The Journal of biological chemistry 276, 29748-53. PMID: 11384984

2. Lin, HC. et al. (2015) Science (New York, N.Y.) 349, 91-5. PMID: 26138980

3. Lin, HC. et al. (2018) Molecular cell 70, 602-613.e3. PMID: 29775578

4. Koren, I. et al. (2018) Cell 173, 1622-1635.e14. PMID: 29779948

5. Zhao, S. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2308870120. PMID: 37844242

6. Liwocha, J. et al. (2024) Nature structural & molecular biology 31, 378-389. PMID: 38326650

7. Kamura, T. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 10430-5. PMID: 10973499

8. Min, KW. et al. (2003) The Journal of biological chemistry 278, 15905-10. PMID: 12609982

9. Kelsall, IR. et al. (2013) The EMBO journal 32, 2848-60. PMID: 24076655

For research use only.

产品说明书

Anti-Human CUL2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CUL2 Polyclonal Antibody (HC301014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CUL2 Polyclonal Antibody (HC301014)

概述

图片

参考文献

产品说明书

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