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Anti-Human CUL2 Polyclonal Antibody (ARO-A12015)

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概述
货号ARO-A12015
品牌ProteoGenix
描述
Anti-Human CUL2 Polyclonal Antibody (ARO-A12015) is a rabbit polyclonal antibody detecting Cullin-2, CUL2, CUL-2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CUL2 (Thr526-Ala745).
靶标Cullin-2, CUL2, CUL-2
纯化方式Purified by antigen affinity column.
Accession号Q13617
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cullin-2 (CUL2) is a ~86 kDa protein. Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. CUL2 serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the E2 ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

1. Kamura, T. et al. (2001) The Journal of biological chemistry 276, 29748-53. PMID: 11384984
2. Lin, HC. et al. (2015) Science (New York, N.Y.) 349, 91-5. PMID: 26138980
3. Lin, HC. et al. (2018) Molecular cell 70, 602-613.e3. PMID: 29775578
4. Koren, I. et al. (2018) Cell 173, 1622-1635.e14. PMID: 29779948
5. Zhao, S. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2308870120. PMID: 37844242
6. Liwocha, J. et al. (2024) Nature structural & molecular biology 31, 378-389. PMID: 38326650
7. Kamura, T. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 10430-5. PMID: 10973499
8. Min, KW. et al. (2003) The Journal of biological chemistry 278, 15905-10. PMID: 12609982
9. Kelsall, IR. et al. (2013) The EMBO journal 32, 2848-60. PMID: 24076655
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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