Anti-Human TRIM69 Polyclonal Antibody (HP348014)

价格:

规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HP348014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human TRIM69 (Thr331-Gln500).

Tripartite motif-containing protein 69, RFP-like domain-containing protein trimless, RNF36, E3 ubiquitin-protein ligase TRIM69, RING finger protein 36, RING-type E3 ubiquitin transferase TRIM69, TRIM69

Purified by antigen affinity column.

Accession号

Q86WT6

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

E3 ubiquitin-protein ligase TRIM69 is a ~57 kDa protein. E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination.

1. Han, Y. et al. (2012) Biochemical and biophysical research communications 429, 6-11. PMID: 23131556

2. Wang, K. et al. (2018) PLoS pathogens 14, e1007287. PMID: 30142214

3. Rihn, SJ. et al. (2019) Journal of virology 93. PMID: 31375575

4. Kueck, T. et al. (2019) Journal of virology 93. PMID: 31578292

5. Rong, X. et al. (2019) Redox biology 22, 101157. PMID: 30844644

6. Song, Y. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2211467119. PMID: 36251989

7. Wang, Y. et al. (2023) Nucleic acids research 51, 10568-10589. PMID: 37739411

For research use only.

产品说明书

Anti-Human TRIM69 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TRIM69 Polyclonal Antibody (HP348014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TRIM69 Polyclonal Antibody (HP348014)

概述

图片

参考文献

产品说明书

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