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Anti-Human TRIM69 Polyclonal Antibody (ARO-A11874)

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概述
货号ARO-A11874
品牌ProteoGenix
描述
Anti-Human TRIM69 Polyclonal Antibody (ARO-A11874) is a rabbit polyclonal antibody detecting Tripartite motif-containing protein 69, RFP-like domain-containing protein trimless, RNF36, E3 ubiquitin-protein ligase TRIM69, RING finger protein 36, RING-type E3 ubiquitin transferase TRIM69, TRIM69 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TRIM69 (Thr331-Gln500).
靶标Tripartite motif-containing protein 69, RFP-like domain-containing protein trimless, RNF36, E3 ubiquitin-protein ligase TRIM69, RING finger protein 36, RING-type E3 ubiquitin transferase TRIM69, TRIM69
纯化方式Purified by antigen affinity column.
Accession号Q86WT6
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

E3 ubiquitin-protein ligase TRIM69 is a ~57 kDa protein. E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination.

1. Han, Y. et al. (2012) Biochemical and biophysical research communications 429, 6-11. PMID: 23131556
2. Wang, K. et al. (2018) PLoS pathogens 14, e1007287. PMID: 30142214
3. Rihn, SJ. et al. (2019) Journal of virology 93. PMID: 31375575
4. Kueck, T. et al. (2019) Journal of virology 93. PMID: 31578292
5. Rong, X. et al. (2019) Redox biology 22, 101157. PMID: 30844644
6. Song, Y. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2211467119. PMID: 36251989
7. Wang, Y. et al. (2023) Nucleic acids research 51, 10568-10589. PMID: 37739411
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human TRIM69 Polyclonal Antibody

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