Anti-Human ACSS2 Polyclonal Antibody (HP274014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

HP274014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human ACSS2 (Asp346-Gln701).

ACS, AceCS1, ACSS2, Acyl-CoA synthetase short-chain family member 2, Propionate--CoA ligase, Acyl-activating enzyme, Acetate--CoA ligase, ACAS2, Acetyl-CoA synthetase, Acetyl-CoA synthetase 1, AceCS, Acetyl-coenzyme A synthetase, cytoplasmic

Purified by antigen affinity column.

Accession号

Q9NR19

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2) is a ~78 kDa protein. Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis. Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription.

1. Luong, A. et al. (2000) The Journal of biological chemistry 275, 26458-66. PMID: 10843999

2. Yoshimura, Y. et al. (2017) Journal of biochemistry 161, 279-289. PMID: 28003429

3. Li, X. et al. (2017) Molecular cell 66, 684-697.e9. PMID: 28552616

For research use only.

产品说明书

Anti-Human ACSS2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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实验相关试剂

Anti-Human ACSS2 Polyclonal Antibody (HP274014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ACSS2 Polyclonal Antibody (HP274014)

概述

图片

参考文献

产品说明书

相关产品推荐

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