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Anti-Human ACSS2 Polyclonal Antibody (PTX20261)

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概述
货号PTX20261
品牌ProteoGenix
描述
Anti-Human ACSS2 Polyclonal Antibody (PTX20261) is a rabbit polyclonal antibody detecting ACS, AceCS1, ACSS2, Acyl-CoA synthetase short-chain family member 2, Propionate--CoA ligase, Acyl-activating enzyme, Acetate--CoA ligase, ACAS2, Acetyl-CoA synthetase, Acetyl-CoA synthetase 1, AceCS, Acetyl-coenzyme A synthetase, cytoplasmic in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ACSS2 (Asp346-Gln701).
靶标ACS, AceCS1, ACSS2, Acyl-CoA synthetase short-chain family member 2, Propionate--CoA ligase, Acyl-activating enzyme, Acetate--CoA ligase, ACAS2, Acetyl-CoA synthetase, Acetyl-CoA synthetase 1, AceCS, Acetyl-coenzyme A synthetase, cytoplasmic
纯化方式Purified by antigen affinity column.
Accession号Q9NR19
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2) is a ~78 kDa protein. Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis. Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription.

1. Luong, A. et al. (2000) The Journal of biological chemistry 275, 26458-66. PMID: 10843999
2. Yoshimura, Y. et al. (2017) Journal of biochemistry 161, 279-289. PMID: 28003429
3. Li, X. et al. (2017) Molecular cell 66, 684-697.e9. PMID: 28552616
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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