

| 货号 | HT233014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FLIP/CFLAR (Asp31-Asn184). | ||||||||
| 靶标 | CLARP, Inhibitor of FLICE, Casper, CASP8 and FADD-like apoptosis regulator, Caspase homolog, I-FLICE, MRIT, CASP8AP1, CFLAR, Cellular FLICE-like inhibitory protein, Caspase-like apoptosis regulatory protein, c-FLIP, MACH-related inducer of toxicity, Usurpin, FADD-like antiapoptotic molecule 1, CASH, FLAME-1, Caspase-eight-related protein | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | O15519 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | CASP8 and FADD-like apoptosis regulator (FLIP/CFLAR) is a ~55 kDa protein. Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. 1. An, W. et al. (2019) Journal of experimental & clinical cancer research : CR 38, 181. PMID: 31046799 | ||||||||
| Note | For research use only. |

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