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Anti-Human FLIP/CFLAR Polyclonal Antibody (ARO-A11760)

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概述
货号ARO-A11760
品牌ProteoGenix
描述
Anti-Human FLIP/CFLAR Polyclonal Antibody (ARO-A11760) is a rabbit polyclonal antibody detecting CLARP, Inhibitor of FLICE, Casper, CASP8 and FADD-like apoptosis regulator, Caspase homolog, I-FLICE, MRIT, CASP8AP1, CFLAR, Cellular FLICE-like inhibitory protein, Caspase-like apoptosis regulatory protein, c-FLIP, MACH-related inducer of toxicity, Usurpin, FADD-like antiapoptotic molecule 1, CASH, FLAME-1, Caspase-eight-related protein in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human FLIP/CFLAR (Asp31-Asn184).
靶标CLARP, Inhibitor of FLICE, Casper, CASP8 and FADD-like apoptosis regulator, Caspase homolog, I-FLICE, MRIT, CASP8AP1, CFLAR, Cellular FLICE-like inhibitory protein, Caspase-like apoptosis regulatory protein, c-FLIP, MACH-related inducer of toxicity, Usurpin, FADD-like antiapoptotic molecule 1, CASH, FLAME-1, Caspase-eight-related protein
纯化方式Purified by antigen affinity column.
Accession号O15519
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

CASP8 and FADD-like apoptosis regulator (FLIP/CFLAR) is a ~55 kDa protein. Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

1. An, W. et al. (2019) Journal of experimental & clinical cancer research : CR 38, 181. PMID: 31046799
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human FLIP/CFLAR Polyclonal Antibody

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