

| 货号 | HF500014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CBR3 (Met1-Trp277). | ||||||||
| 靶标 | Carbonyl reductase [NADPH] 3, Short chain dehydrogenase/reductase family 21C member 2, NADPH-dependent carbonyl reductase 3, CBR3 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | O75828 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Carbonyl reductase [NADPH] 3 (CBR3) is a ~30 kDa protein. Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. 1. Miura, T. et al. (2008) Molecular and cellular biochemistry 315, 113-21. PMID: 18493841 2. Lakhman, SS. et al. (2005) Drug metabolism and disposition: the biological fate of chemicals 33, 254-7. PMID: 15537833 3. Pilka, ES. et al. (2009) PloS one 4, e7113. PMID: 19841672 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-CBR3 polyclonal antibody at 1μg/ml on various samples.
Lane 1: MCF7 cell lysate
Lane 2: Mouse ovary lysate
Lane 3: Mouse uterus lysate



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