Anti-PPP3CA Polyclonal Antibody (HC519014)

价格:

规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HC519014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human PPP3CA (Ile7-Ser301).

CAM-PRP catalytic subunit, CNA, Calmodulin-dependent calcineurin A subunit alpha isoform, CALNA, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, PPP3CA

Purified by antigen affinity column.

Accession号

Q08209

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Protein phosphatase 3 catalytic subunit alpha (PPP3CA) is a ~58 kDa protein. Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals.

1. Wang, Y. et al. (2005) The Journal of biological chemistry 280, 12683-9. PMID: 15671020

2. Cereghetti, GM. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15803-8. PMID: 18838687

3. Kilka, S. et al. (2009) Biochemistry 48, 1900-10. PMID: 19154138

4. Grigoriu, S. et al. (2013) PLoS biology 11, e1001492. PMID: 23468591

5. Rydzanicz, M. et al. (2019) European journal of human genetics : EJHG 27, 61-69. PMID: 30254215

6. Li, H. et al. (2007) Journal of molecular biology 369, 1296-306. PMID: 17498738

7. Takeuchi, K. et al. (2007) Structure (London, England : 1993) 15, 587-97. PMID: 17502104

8. Li, H. et al. (2012) Nature structural & molecular biology 19, 337-45. PMID: 22343722

9. Sheftic, SR. et al. (2016) Scientific reports 6, 38920. PMID: 27974827

For research use only.

产品说明书

Anti-PPP3CA Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PPP3CA Polyclonal Antibody (HC519014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PPP3CA Polyclonal Antibody (HC519014)

概述

图片

参考文献

产品说明书

相关产品推荐

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