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Anti-PPP3CA Polyclonal Antibody (ARO-A11717)

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概述
货号ARO-A11717
品牌ProteoGenix
描述
Anti-PPP3CA Polyclonal Antibody (ARO-A11717) is a rabbit polyclonal antibody detecting CAM-PRP catalytic subunit, CNA, Calmodulin-dependent calcineurin A subunit alpha isoform, CALNA, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, PPP3CA in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human PPP3CA (Ile7-Ser301).
靶标CAM-PRP catalytic subunit, CNA, Calmodulin-dependent calcineurin A subunit alpha isoform, CALNA, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, PPP3CA
纯化方式Purified by antigen affinity column.
Accession号Q08209
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Protein phosphatase 3 catalytic subunit alpha (PPP3CA) is a ~58 kDa protein. Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals.

1. Wang, Y. et al. (2005) The Journal of biological chemistry 280, 12683-9. PMID: 15671020
2. Cereghetti, GM. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15803-8. PMID: 18838687
3. Kilka, S. et al. (2009) Biochemistry 48, 1900-10. PMID: 19154138
4. Grigoriu, S. et al. (2013) PLoS biology 11, e1001492. PMID: 23468591
5. Rydzanicz, M. et al. (2019) European journal of human genetics : EJHG 27, 61-69. PMID: 30254215
6. Li, H. et al. (2007) Journal of molecular biology 369, 1296-306. PMID: 17498738
7. Takeuchi, K. et al. (2007) Structure (London, England : 1993) 15, 587-97. PMID: 17502104
8. Li, H. et al. (2012) Nature structural & molecular biology 19, 337-45. PMID: 22343722
9. Sheftic, SR. et al. (2016) Scientific reports 6, 38920. PMID: 27974827
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-PPP3CA Polyclonal Antibody

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