Anti-GRK2 Polyclonal Antibody (HB035014)

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100ug

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HB035014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human GRK2 (Asp398-Leu640).

G-protein coupled receptor kinase 2, GRK2, ADRBK1, Beta-adrenergic receptor kinase 1, BARK1, BARK, Beta-ARK-1

Purified by antigen affinity column.

Accession号

P25098

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Beta-adrenergic receptor kinase 1 (GRK2) is a ~79 kDa protein. Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses. Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor.

1. Pao, CS. et al. (2009) Biochemistry 48, 7325-33. PMID: 19715378

2. Guo, Q. et al. (2011) PloS one 6, e22559. PMID: 21799898

3. Gupta, K. et al. (2012) PloS one 7, e46369. PMID: 23077507

4. Aziziyeh, AI. et al. (2009) Cellular signalling 21, 1207-17. PMID: 19306925

5. Yim, PD. et al. (2019) American journal of physiology. Lung cellular and molecular physiology 316, L82-L93. PMID: 30284927

For research use only.

产品说明书

Anti-GRK2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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Anti-GRK2 Polyclonal Antibody (HB035014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GRK2 Polyclonal Antibody (HB035014)

概述

图片

参考文献

产品说明书

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