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Anti-GRK2 Polyclonal Antibody (PTX20319)

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概述
货号PTX20319
品牌ProteoGenix
描述
Anti-GRK2 Polyclonal Antibody (PTX20319) is a rabbit polyclonal antibody detecting G-protein coupled receptor kinase 2, GRK2, ADRBK1, Beta-adrenergic receptor kinase 1, BARK1, BARK, Beta-ARK-1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GRK2 (Asp398-Leu640).
靶标G-protein coupled receptor kinase 2, GRK2, ADRBK1, Beta-adrenergic receptor kinase 1, BARK1, BARK, Beta-ARK-1
纯化方式Purified by antigen affinity column.
Accession号P25098
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Beta-adrenergic receptor kinase 1 (GRK2) is a ~79 kDa protein. Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses. Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor.

1. Pao, CS. et al. (2009) Biochemistry 48, 7325-33. PMID: 19715378
2. Guo, Q. et al. (2011) PloS one 6, e22559. PMID: 21799898
3. Gupta, K. et al. (2012) PloS one 7, e46369. PMID: 23077507
4. Aziziyeh, AI. et al. (2009) Cellular signalling 21, 1207-17. PMID: 19306925
5. Yim, PD. et al. (2019) American journal of physiology. Lung cellular and molecular physiology 316, L82-L93. PMID: 30284927
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-GRK2 Polyclonal Antibody

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