

| 货号 | HW546014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ALDH7A1 (Met1-Gln539). | ||||||||
| 靶标 | ALDH7A1, Delta1-piperideine-6-carboxylate dehydrogenase, Antiquitin-1, P6c dehydrogenase, Alpha-AASA dehydrogenase, Alpha-aminoadipic semialdehyde dehydrogenase, Aldehyde dehydrogenase family 7 member A1, Betaine aldehyde dehydrogenase, ATQ1 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P49419 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) is a ~58 kDa protein. Aldehyde dehydrogenase enzyme that mediates important protective effects. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in cellular defense against hyperosmotic stress by metabolizing betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. 1. Mills, PB. et al. (2006) Nature medicine 12, 307-9. PMID: 16491085 2. Brocker, C. et al. (2010) The Journal of biological chemistry 285, 18452-63. PMID: 20207735 3. Mills, PB. et al. (2010) Brain : a journal of neurology 133, 2148-59. PMID: 20554659 4. Brocker, C. et al. (2011) Chemico-biological interactions 191, 269-77. PMID: 21338592 5. Luo, M. et al. (2015) ACS chemical biology 10, 693-7. PMID: 25554827 6. Laciak, AR. et al. (2020) The FEBS journal 287, 173-189. PMID: 31302938 7. Laciak, AR. et al. (2020) Journal of inherited metabolic disease 43, 635-644. PMID: 31652343 8. Korasick, DA. et al. (2024) Chemico-biological interactions 394, 110993. PMID: 38604394 9. Yang, JS. et al. (2025) Cell 188, 2569-2585.e20. PMID: 40233740 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-ALDH7A1 polyclonal antibody at 1µg/ml on various samples.
Lane 1: 293T cell lysate
Lane 2: Mouse liver lysate
Lane 3: Rat liver lysate
Lane 4: Rat kidney lysate



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