

| 货号 | HV707014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AP2M1 (Arg170-Cys435). | ||||||||
| 靶标 | Adaptor-related protein complex 2 subunit mu, AP-2 mu chain, CLAPM1, HA2 50 kDa subunit, Plasma membrane adaptor AP-2 50 kDa protein, Adaptin-mu2, AP2M1, KIAA0109, Clathrin coat assembly protein AP50, Adaptor protein complex AP-2 subunit mu, Clathrin assembly protein complex 2 mu medium chain, AP-2 complex subunit mu, Clathrin coat-associated protein AP50 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q96CW1 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | AP-2 complex subunit mu (AP2M1) is a ~49 kDa protein. Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. 1. Fraile-Ramos, A. et al. (2003) Traffic (Copenhagen, Denmark) 4, 243-53. PMID: 12694563 2. Motley, A. et al. (2003) The Journal of cell biology 162, 909-18. PMID: 12952941 3. Nakatsu, F. et al. (2003) Cell structure and function 28, 419-29. PMID: 14745134 4. Huang, F. et al. (2004) The Journal of biological chemistry 279, 16657-61. PMID: 14985334 5. Owen, DJ. et al. (2004) Annual review of cell and developmental biology 20, 153-91. PMID: 15473838 6. Helbig, I. et al. (2019) American journal of human genetics 104, 1060-1072. PMID: 31104773 9. Marcello, E. et al. (2013) The Journal of clinical investigation 123, 2523-38. PMID: 23676497 | ||||||||
| Note | For research use only. |

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