

| 货号 | HP907014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TNS3 (Met1-Val242). | ||||||||
| 靶标 | Tumor endothelial marker 6, TPP, Tensin-like SH2 domain-containing protein 1, Tensin-3, TNS3, TENS1, TEM6 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q68CZ2 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Tensin-3 (TNS3) is a ~155 kDa protein. May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization. Enhances RHOA activation in the presence of DLC1. 1. Katz, M. et al. (2007) Nature cell biology 9, 961-9. PMID: 17643115 2. Shih, YP. et al. (2015) Biochimica et biophysica acta 1853, 3258-65. PMID: 26427649 3. Cao, X. et al. (2015) Nature communications 6, 7721. PMID: 26166433 4. Zuidema, A. et al. (2022) The Journal of cell biology 221. PMID: 35687021 5. Park, GC. et al. (2019) Cells 9. PMID: 31905841 | ||||||||
| Note | For research use only. |

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