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Anti-TNS3 Polyclonal Antibody (ARO-A11529)

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概述
货号ARO-A11529
品牌ProteoGenix
描述
Anti-TNS3 Polyclonal Antibody (ARO-A11529) is a rabbit polyclonal antibody detecting Tumor endothelial marker 6, TPP, Tensin-like SH2 domain-containing protein 1, Tensin-3, TNS3, TENS1, TEM6 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TNS3 (Met1-Val242).
靶标Tumor endothelial marker 6, TPP, Tensin-like SH2 domain-containing protein 1, Tensin-3, TNS3, TENS1, TEM6
纯化方式Purified by antigen affinity column.
Accession号Q68CZ2
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Tensin-3 (TNS3) is a ~155 kDa protein. May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization. Enhances RHOA activation in the presence of DLC1.

1. Katz, M. et al. (2007) Nature cell biology 9, 961-9. PMID: 17643115
2. Shih, YP. et al. (2015) Biochimica et biophysica acta 1853, 3258-65. PMID: 26427649
3. Cao, X. et al. (2015) Nature communications 6, 7721. PMID: 26166433
4. Zuidema, A. et al. (2022) The Journal of cell biology 221. PMID: 35687021
5. Park, GC. et al. (2019) Cells 9. PMID: 31905841
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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