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Anti-BCL11A Polyclonal Antibody (HP181014)

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概述
货号HP181014
品牌abinScience
种属反应性Human, Mouse
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human BCL11A (Met1-Arg210).
靶标B-cell CLL/lymphoma 11A, EVI-9, CTIP1, EVI9, Zinc finger protein 856, KIAA1809, B-cell lymphoma/leukemia 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, ZNF856, BCL11A, BCL-11A
纯化方式Purified by antigen affinity column.
Accession号Q9H165
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息
应用方法 稀释比例
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

BCL11 transcription factor A (BCL11A) is a ~91 kDa protein. Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development.

1. Liu, H. et al. (2006) Molecular cancer 5, 18. PMID: 16704730
2. Liu, N. et al. (2018) Cell 173, 430-442.e17. PMID: 29606353
3. Kadoch, C. et al. (2013) Nature genetics 45, 592-601. PMID: 23644491
4. Zheng, G. et al. (2024) Science (New York, N.Y.) 386, 1010-1018. PMID: 39607926
5. Viennet, T. et al. (2024) Structure (London, England : 1993) 32, 2276-2286.e4. PMID: 39423807
6. Bauer, DE. et al. (2015) Current opinion in genetics & development 33, 62-70. PMID: 26375765
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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