

| 货号 | HP181014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BCL11A (Met1-Arg210). | ||||||||
| 靶标 | B-cell CLL/lymphoma 11A, EVI-9, CTIP1, EVI9, Zinc finger protein 856, KIAA1809, B-cell lymphoma/leukemia 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, ZNF856, BCL11A, BCL-11A | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q9H165 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | BCL11 transcription factor A (BCL11A) is a ~91 kDa protein. Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. 1. Liu, H. et al. (2006) Molecular cancer 5, 18. PMID: 16704730 2. Liu, N. et al. (2018) Cell 173, 430-442.e17. PMID: 29606353 3. Kadoch, C. et al. (2013) Nature genetics 45, 592-601. PMID: 23644491 4. Zheng, G. et al. (2024) Science (New York, N.Y.) 386, 1010-1018. PMID: 39607926 5. Viennet, T. et al. (2024) Structure (London, England : 1993) 32, 2276-2286.e4. PMID: 39423807 6. Bauer, DE. et al. (2015) Current opinion in genetics & development 33, 62-70. PMID: 26375765 | ||||||||
| Note | For research use only. |

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