Recombinant Human BCL11A Protein, N-His (PX-P5516)
概述
图片
参考文献
概述
货号
PX-P5516
品牌
ProteoGenix
描述
Recombinant Human BCL11A Protein, N-His (PX-P5516) expressed in E. coli, Purity: >90% as determined by SDS-PAGE..
Highlights
High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy.
E. coli Expression — Optimized for functional studies.
表达系统
E. coli
Accession号
Q9H165
蛋白长度
Met1-Arg210
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
25.45 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
B-cell CLL/lymphoma 11A, EVI-9, CTIP1, EVI9, Zinc finger protein 856, KIAA1809, B-cell lymphoma/leukemia 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, ZNF856, BCL11A, BCL-11A
背景
BCL11 transcription factor A (BCL11A) is a ~91 kDa protein. Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development.
1. Liu, H. et al. (2006) Molecular cancer 5, 18. PMID: 16704730
2. Liu, N. et al. (2018) Cell 173, 430-442.e17. PMID: 29606353
3. Kadoch, C. et al. (2013) Nature genetics 45, 592-601. PMID: 23644491
4. Zheng, G. et al. (2024) Science (New York, N.Y.) 386, 1010-1018. PMID: 39607926
5. Viennet, T. et al. (2024) Structure (London, England : 1993) 32, 2276-2286.e4. PMID: 39423807
6. Bauer, DE. et al. (2015) Current opinion in genetics & development 33, 62-70. PMID: 26375765
