

| 货号 | HW698014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DUT (Met112-Asn252). | ||||||||
| 靶标 | dUTP pyrophosphatase, DUT, dUTPase, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P33316 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) is a ~26 kDa protein. Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. Essential for embryonic development. 1. Varga, B. et al. (2007) FEBS letters 581, 4783-8. PMID: 17880943 2. Ladner, RD. et al. (1996) The Journal of biological chemistry 271, 7745-51. PMID: 8631816 3. Mol, CD. et al. (1996) Structure (London, England : 1993) 4, 1077-92. PMID: 8805593 | ||||||||
| Note | For research use only. |

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