Anti-DNM2 Polyclonal Antibody (HW618014)

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50ug
100ug

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概述
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参考文献
产品说明书

HW618014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human DNM2 (Met1-Gly230).

DNM2, Dynamin-2, DYN2

Purified by antigen affinity column.

Accession号

P50570

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Dynamin-2 (DNM2) is a ~98 kDa protein. Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission. Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes. During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers.

1. Züchner, S. et al. (2005) Nature genetics 37, 289-94. PMID: 15731758

2. Mooren, OL. et al. (2009) The Journal of biological chemistry 284, 23995-4005. PMID: 19605363

3. Bitoun, M. et al. (2009) Human mutation 30, 1419-27. PMID: 19623537

4. Yeung, ML. et al. (2021) Cell 184, 2212-2228.e12. PMID: 33713620

5. Tassin, TC. et al. (2021) Frontiers in cellular neuroscience 15, 745940. PMID: 34744632

6. Fabrizi, GM. et al. (2007) Neurology 69, 291-5. PMID: 17636067

8. Søreng, K. et al. (2018) EMBO reports 19. PMID: 29437695

For research use only.

Western blot

Western blot analysis was performed using anti-DNM2 polyclonal antibody at 1µg/ml on various samples.
Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate

产品说明书

Anti-DNM2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-DNM2 Polyclonal Antibody (HW618014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-DNM2 Polyclonal Antibody (HW618014)

概述

图片

参考文献

产品说明书

相关产品推荐

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