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Anti-DNM2 Polyclonal Antibody (ARO-A11298)

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概述
货号ARO-A11298
品牌ProteoGenix
描述
Anti-DNM2 Polyclonal Antibody (ARO-A11298) is a rabbit polyclonal antibody detecting DNM2, Dynamin-2, DYN2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human DNM2 (Met1-Gly230).
靶标DNM2, Dynamin-2, DYN2
纯化方式Purified by antigen affinity column.
Accession号P50570
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Dynamin-2 (DNM2) is a ~98 kDa protein. Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission. Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes. During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers.

1. Züchner, S. et al. (2005) Nature genetics 37, 289-94. PMID: 15731758
2. Mooren, OL. et al. (2009) The Journal of biological chemistry 284, 23995-4005. PMID: 19605363
3. Bitoun, M. et al. (2009) Human mutation 30, 1419-27. PMID: 19623537
4. Yeung, ML. et al. (2021) Cell 184, 2212-2228.e12. PMID: 33713620
5. Tassin, TC. et al. (2021) Frontiers in cellular neuroscience 15, 745940. PMID: 34744632
6. Fabrizi, GM. et al. (2007) Neurology 69, 291-5. PMID: 17636067
8. Søreng, K. et al. (2018) EMBO reports 19. PMID: 29437695
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-DNM2 Polyclonal Antibody

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