Anti-Human KCNH2/ERG1 Polyclonal Antibody (HC535014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
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HC535014

abinScience

种属反应性

Human, Mouse, Rat

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human KCNH2/ERG1 (Pro10-Lys135).

H-ERG, ERG, HERG, hERG1, hERG-1, Potassium voltage-gated channel subfamily H member 2, ERG-1, KCNH2, Eag homolog, ERG1, Eag-related protein 1, Ether-a-go-go-related gene potassium channel 1, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related protein 1

Purified by antigen affinity column.

Accession号

Q12809

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Voltage-gated inwardly rectifying potassium channel KCNH2 (ERG1) is a ~126 kDa protein. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity.

1. Abbott, GW. et al. (1999) Cell 97, 175-87. PMID: 10219239

2. Kagan, A. et al. (2000) The Journal of biological chemistry 275, 11241-8. PMID: 10753933

3. Paulussen, A. et al. (2000) Human mutation 15, 483. PMID: 10790218

4. Cui, J. et al. (2000) Current biology : CB 10, 671-4. PMID: 10837251

5. Yang, P. et al. (2002) Circulation 105, 1943-8. PMID: 11997281

6. Gong, Q. et al. (2002) American journal of physiology. Heart and circulatory physiology 283, H77-84. PMID: 12063277

7. Guasti, L. et al. (2008) Molecular and cellular biology 28, 5043-60. PMID: 18559421

8. Aidery, P. et al. (2012) Biochemical and biophysical research communications 418, 830-5. PMID: 22314138

9. Ng, CA. et al. (2012) PloS one 7, e31640. PMID: 22359612

10. Kang, Y. et al. (2015) The Biochemical journal 472, 71-82. PMID: 26363003

For research use only.

Western blot

Western blot analysis was performed using anti-KCNH2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
Lane 2: 293T cell lysate

产品说明书

Anti-Human KCNH2/ERG1 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

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实验相关试剂

Anti-Human KCNH2/ERG1 Polyclonal Antibody (HC535014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KCNH2/ERG1 Polyclonal Antibody (HC535014)

概述

图片

参考文献

产品说明书

相关产品推荐

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