

| 货号 | HC535022 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Human KCNH2/ERG1 Protein, N-His (HC535022) expressed in E. coli, spanning Pro10-Lys135. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | E. coli |
| Accession号 | Q12809 |
| 蛋白长度 | Pro10-Lys135 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 16.57 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | ERG, ERG-1, ERG1, Eag homolog, Eag-related protein 1, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, HERG, KCNH2, Potassium voltage-gated channel subfamily H member 2, Voltage-gated inwardly rectifying potassium channel KCNH2, Voltage-gated potassium channel subunit Kv11.1, hERG-1, hERG1 |
| 背景 | Voltage-gated inwardly rectifying potassium channel KCNH2 is a ~126 kDa protein. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity. 1. Abbott, GW. et al. (1999) Cell 97, 175-87. PMID: 10219239 2. Kagan, A. et al. (2000) The Journal of biological chemistry 275, 11241-8. PMID: 10753933 3. Paulussen, A. et al. (2000) Human mutation 15, 483. PMID: 10790218 4. Cui, J. et al. (2000) Current biology : CB 10, 671-4. PMID: 10837251 5. Yang, P. et al. (2002) Circulation 105, 1943-8. PMID: 11997281 6. Gong, Q. et al. (2002) American journal of physiology. Heart and circulatory physiology 283, H77-84. PMID: 12063277 7. Guasti, L. et al. (2008) Molecular and cellular biology 28, 5043-60. PMID: 18559421 8. Aidery, P. et al. (2012) Biochemical and biophysical research communications 418, 830-5. PMID: 22314138 9. Ng, CA. et al. (2012) PloS one 7, e31640. PMID: 22359612 10. Kang, Y. et al. (2015) The Biochemical journal 472, 71-82. PMID: 26363003 |
| Note | For research use only |

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