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Human KCNH2/ERG1 Recombinant Protein (N-His) (HC535022)

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  • 100ug
  • 1mg
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概述
货号HC535022
品牌abinScience
描述
Recombinant Human KCNH2/ERG1 Protein, N-His (HC535022) expressed in E. coli, spanning Pro10-Lys135. Purity: >90% by SDS-PAGE.
Highlights
  • His-Tagged — N-terminal 6×His tag for IMAC purification.
  • E. coli Expression — High-yield, cost-effective production.
  • High Purity — >90% purity verified by SDS-PAGE.
表达系统E. coli
Accession号Q12809
蛋白长度Pro10-Lys135
应用ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属Homo sapiens (Human)
性质Recombinant
内毒素水平Please contact with the lab for this information.
纯度>90% as determined by SDS-PAGE.
预测分子量16.57 kDa
状态Lyophilized
保存溶液 Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

重悬Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名ERG, ERG-1, ERG1, Eag homolog, Eag-related protein 1, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, HERG, KCNH2, Potassium voltage-gated channel subfamily H member 2, Voltage-gated inwardly rectifying potassium channel KCNH2, Voltage-gated potassium channel subunit Kv11.1, hERG-1, hERG1
背景

Voltage-gated inwardly rectifying potassium channel KCNH2 is a ~126 kDa protein. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity.

1. Abbott, GW. et al. (1999) Cell 97, 175-87. PMID: 10219239
2. Kagan, A. et al. (2000) The Journal of biological chemistry 275, 11241-8. PMID: 10753933
3. Paulussen, A. et al. (2000) Human mutation 15, 483. PMID: 10790218
4. Cui, J. et al. (2000) Current biology : CB 10, 671-4. PMID: 10837251
5. Yang, P. et al. (2002) Circulation 105, 1943-8. PMID: 11997281
6. Gong, Q. et al. (2002) American journal of physiology. Heart and circulatory physiology 283, H77-84. PMID: 12063277
7. Guasti, L. et al. (2008) Molecular and cellular biology 28, 5043-60. PMID: 18559421
8. Aidery, P. et al. (2012) Biochemical and biophysical research communications 418, 830-5. PMID: 22314138
9. Ng, CA. et al. (2012) PloS one 7, e31640. PMID: 22359612
10. Kang, Y. et al. (2015) The Biochemical journal 472, 71-82. PMID: 26363003
NoteFor research use only
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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