Anti-Human ANKRD27 Polyclonal Antibody (HP196014)

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50ug
100ug

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概述
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参考文献
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HP196014

abinScience

种属反应性

Human

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human ANKRD27 (Met654-Ser902).

ANKRD27, Ankyrin repeat domain-containing protein 27, VPS9 domain-containing protein

Purified by antigen affinity column.

Accession号

Q96NW4

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Ankyrin repeat domain-containing protein 27 (ANKRD27) is a ~116 kDa protein. May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1.

1. Zhang, X. et al. (2006) Journal of cell science 119, 1053-62. PMID: 16525121

2. Wang, F. et al. (2008) Biochemical and biophysical research communications 372, 162-7. PMID: 18477474

3. Schäfer, IB. et al. (2012) Nature structural & molecular biology 19, 1300-9. PMID: 23104059

4. Burgo, A. et al. (2012) Developmental cell 23, 166-80. PMID: 22705394

5. Burgo, A. et al. (2009) EMBO reports 10, 1117-24. PMID: 19745841

6. Hesketh, GG. et al. (2014) Developmental cell 29, 591-606. PMID: 24856514

For research use only.

产品说明书

Anti-Human ANKRD27 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

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试剂盒

实验相关试剂

Anti-Human ANKRD27 Polyclonal Antibody (HP196014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ANKRD27 Polyclonal Antibody (HP196014)

概述

图片

参考文献

产品说明书

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