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Anti-Human ANKRD27 Polyclonal Antibody (ARO-A11126)

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概述
货号ARO-A11126
品牌ProteoGenix
描述
Anti-Human ANKRD27 Polyclonal Antibody (ARO-A11126) is a rabbit polyclonal antibody detecting ANKRD27, Ankyrin repeat domain-containing protein 27, VPS9 domain-containing protein in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ANKRD27 (Met654-Ser902).
靶标ANKRD27, Ankyrin repeat domain-containing protein 27, VPS9 domain-containing protein
纯化方式Purified by antigen affinity column.
Accession号Q96NW4
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ankyrin repeat domain-containing protein 27 (ANKRD27) is a ~116 kDa protein. May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1.

1. Zhang, X. et al. (2006) Journal of cell science 119, 1053-62. PMID: 16525121
2. Wang, F. et al. (2008) Biochemical and biophysical research communications 372, 162-7. PMID: 18477474
3. Schäfer, IB. et al. (2012) Nature structural & molecular biology 19, 1300-9. PMID: 23104059
4. Burgo, A. et al. (2012) Developmental cell 23, 166-80. PMID: 22705394
5. Burgo, A. et al. (2009) EMBO reports 10, 1117-24. PMID: 19745841
6. Hesketh, GG. et al. (2014) Developmental cell 29, 591-606. PMID: 24856514
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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