Anti-Mouse IFN-alpha/beta R1 Polyclonal Antibody (MB823014)

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MB823014

abinScience

种属反应性

Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Mouse IFNAR1 (Asp36-Ile432).

Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Type I interferon receptor 1)

Purified by antigen affinity column.

Accession号

P33896

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. IFNAR1 is the therapeutic target of anifrolumab (Saphnelo).

1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120

2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935

3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679

For research use only.

产品说明书

Anti-Mouse IFN-alpha/beta R1 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IFN-alpha/beta R1 Polyclonal Antibody (MB823014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IFN-alpha/beta R1 Polyclonal Antibody (MB823014)

概述

图片

参考文献

产品说明书

相关产品推荐

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